Randomised double blind placebo controlled trial of inhaled fluticasone propionate in infants with chronic lung disease.
نویسندگان
چکیده
In a double blind randomised controlled trial, 30 infants with chronic lung disease received fluticasone propionate or placebo for one year. There were no significant differences between treatment groups in the incidence of any day or night time symptoms or any other outcome measures.
منابع مشابه
INHALED STEROIDS FOR COPD? A E Tattersfield, T W Harrison Introductory articles Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial
Objectives: To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease. Design: Double blind, placebo controlled study. Setting: Eighteen UK hospitals. Participants: 751 men and women aged between 40 and 75 years with mean forced expiratory volume in one second (FEV1) 5...
متن کاملRandomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial.
OBJECTIVES To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease. DESIGN Double blind, placebo controlled study. SETTING Eighteen UK hospitals. PARTICIPANTS 751 men and women aged between 40 and 75 years with mean forced expiratory volume in one second (FEV(1...
متن کاملCHRONIC OBSTRUCTIVE PULMONARY DISEASE Effect of salmeterol/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial
Background: Airway inflammation in chronic obstructive pulmonary disease (COPD) is characterised by infiltration of CD8+ T cells and CD68+ macrophages and an increased number of neutrophils, whereas few studies have described the presence of eosinophils. Although the anti-inflammatory effects of corticosteroids in stable COPD are unclear, recent studies suggest that combination therapy could be...
متن کاملFluticasone furoate demonstrates efficacy in patients with asthma symptomatic on medium doses of inhaled corticosteroid therapy: an 8-week, randomised, placebo-controlled trial.
BACKGROUND Fluticasone furoate (FF) is a novel inhaled corticosteroid with 24 h activity. FF is being developed as a once-daily treatment in combination with the long-acting β(2) agonist vilanterol trifenatate for asthma and chronic obstructive pulmonary disease. OBJECTIVES To determine the optimal dose(s) of FF for treating patients with asthma. METHODS An 8-week multicentre, randomised, d...
متن کاملWithdrawal of inhaled corticosteroids in people with COPD in primary care: a randomised controlled trial
BACKGROUND Guidelines recommend inhaled corticosteroids (ICS) for patients with severe chronic obstructive pulmonary disease (COPD). Most COPD patients are managed in primary care and receive ICS long-term and irrespective of severity. The effect of withdrawing ICS from COPD patients in primary care is unknown. METHODS In a pragmatic randomised, double-blind, placebo-controlled trial in 31 pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Archives of disease in childhood. Fetal and neonatal edition
دوره 87 1 شماره
صفحات -
تاریخ انتشار 2002